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This dose can be increased to 300/25 mg tablet to be taken once daily in order to control blood pressure after one to two weeks of therapy. The active ingredients are irbesartan and hydrochlorothiazide.. Ask your health care provider for advice. Talk to your doctor if Avalide 300/25mg is right for you. 62 The usual dose of Avalide is 150mg/12. SUPPLEMENT APPROVAL . 08, 84% off the average retail price of $84. 5 mg hydrochlorothiazide, or 300 mg irbesartan and 25 mg hydrochlorothiazide produced mean placebo-adjusted blood pressure reductions at trough (24 hours post dosing) of about 13 to 15/7 to 9 mmHg, 14/9 to 12 mmHg, and 19 to 21/11 to 12 mmHg, respectively We currently have the brand Avalide called Karvezide comes from Turkey manufactured by Sanofi Aventis and generic Irbesartan Hydrochlorothiazidem comes from Canada. Compare head-to-head ratings, side effects, …. 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