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Reduction in the Risk of Cardiovascular Morbidity and Mortality in Hypertensive Patients with Left Ventricular Hypertrophy: In patients with hypertension and left ventricular hypertrophy, losartan, often in combination with hydrochlorothiazide, reduces the risk of cardiovascular morbidity and mortality as measured by the combined incidence of. 5 contains 50 mg of losartan potassium and 12. LOSARTAN; HYDROCHLOROTHIAZIDE (loe SAR tan; hye droe klor oh THYE a zide) is a combination of a drug that relaxes blood vessels and a diuretic. This medicine may also reduce the Hyzaar (Losartan Hydrochlorothiazide) Sale G risk of stroke in certain patients Hyzaar 50/12. 5 (losartan potassium-hydrochlorothiazide), HYZAAR 100/12. 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